Antibodies cross - reactive with E - and P - selectin block both
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منابع مشابه
Antibodies cross-reactive with E- and P-selectin block both E- and P-selectin functions.
E- and P-selectin are inflammation-induced cell adhesion molecules that mediate leukocyte-endothelial cell and leukocyte-platelet interactions. Monoclonal antibodies (MoAbs) specific for either E-selectin or P-selectin are protective in several animal models of inflammatory disease. To generate an MoAb with broader therapeutic potential, MoAbs that bind to both E- and P-selectin were generated ...
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Introduction: Psoriasis is an inflammatory skin disease in which abnormal individual immune reactivity plays an important role. Eselectin and P-selectin are adhesion molecules expressed on vascular endothelial cells in several inflammatory skin diseases, including psoriasis. The aim of the present study was to describe selected immunological changes, concerning adhesion molecules status (sEsele...
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متن کاملRelationships of soluble E-selectin and high-sensitivity C-reactive protein with carotid atherosclerosis in Japanese men.
AIM E-selectin and C-reactive protein have been linked with carotid atherosclerosis; however, the findings on this association have been inconsistent. METHODS AND RESULTS We conducted a cross-sectional study to examine the associations of soluble E-selectin (sE-selectin) and high-sensitivity-CRP (hs-CRP) levels with carotid intima-media thickness (IMT) in 505 Japanese men aged 60-74 years. Ma...
متن کاملThe HNK-1 reactive sulfoglucuronyl glycolipids are ligands for L-selectin and P-selectin but not E-selectin.
E-selectin, L-selectin, and P-selectin are related cell adhesion molecules that bind via their lectin domains to sialyl Lewis x and related carbohydrate determinants. Reports have indicated that sulfated glycolipids and polysaccharides also bind selectins. To extend these findings, we compared binding of selectin-IgG chimeras to immobilized sulfated and sialylated glycosphingolipids. E-, L-, an...
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تاریخ انتشار 1995